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Shuobo Shi


Shuobo Shi

Professor, Full-time, Principal Investigator



M. S. - Ph. D., Biochemical Engineering, 2009, Tianjin University, P.R. China

B. S., Biological Engineering, 2004, Hebei University of Technology, P.R. China 


Specializations: Metabolic Engineering and Synthetic Biology



Research focuses:

Metabolic engineering of microbial cell factories for biofuel productions
Development of genome engineering and synthetic biology tools
Development of automation systems

Recent Publications:

S. Shi, Y. Liang, M. Zhang, E.L. Ang, and H. Zhao (2016) A highly efficient single-step, markerless strategy for multi-copy chromosomal integration of large biochemical pathways in Saccharomyces cerevisiae. Metabolic Engineering, 33:19-27.
S. Shi, T. Si, Z. Liu, H. Zhang, E.L. Ang, and H. Zhao (2016)  Metabolic engineering of a synergistic pathway for n-butanol production in Saccharomyces cerevisiae. Scientific Reports, 6:25675.
S. ShiH. Ji, V. Siewers, and J. Nielsen (2016) Improved production of fatty acids by Saccharomyces cerevisiae through screening a cDNA library from the oleaginous yeast Yarrowia lipolytica. FEMS Yeast Research, 16(1): 108
S. Shi, J.O. Valle-Rodríguez, V. Siewers, and J. Nielsen (2014) Engineering of chromosomal wax ester synthase integrated Saccharomyces cerevisiae mutants for improved biosynthesis of fatty acid ethyl esters. Biotechnology and Bioengineering, 111: 1740–1747.
S. Shi, Y. Chen, V. Siewers, and J. Nielsen (2014) Improving production of malonyl-CoA derived metabolites by abolishing Snf1-dependent regulation of Acc1. mBio, 5(3): e01130-14.
J. O. Valle-Rodríguez*, S. Shi *, V. Siewersand J. Nielsen (2014)  Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid ethyl esters, and advanced biofuel, by eliminating non-essential fatty acid utilization pathways. Applied Energy, 115: 226-232. (*contributed equally)
S. Shi, J. O. Valle-Rodríguez, S. Khoomrung, V. Siewers, and J. Nielsen (2012) Functional expression and characterization of five wax ester synthases in Saccharomyces cerevisiae and their utility for biodiesel production. Biotechnology for Biofuels 5: 7.

S. Shi, T. Chen, Z. Zhang, X. Chen, and X. Zhao (2009) Transcriptome analysis guided metabolic engineering of Bacillus subtilis for riboflavin production. Metabolic Engineering, 11: 243-252.





Phone: 13263109231


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